Table 3.
Baseline characteristics of sham-LV-GFP, sham-LV-miR-133a, CHF-LV-GFP, and CHF-LV-miR-133a rats
| Sham-LV-GFP | CHF-LV-GFP | Sham-LV-miR-133a | CHF-LV-miR-133a | |
|---|---|---|---|---|
| Body weight, g | 386.7 ± 6.2 | 380.6 ± 5.1 | 384.1 ± 6.0 | 376.4 ± 5.3 |
| Infarct size, %left ventricle | 0 | 34.9 ± 1.9* | 0 | 34.3 ± 2.0 |
| MAP, mmHg | 86.6 ± 8.3 | 88.3 ± 6.9 | 83.5 ± 4.1 | 84.7 ± 3.4 |
| HR, beats/min | 262.4 ± 15.3 | 319.2 ± 30.4 | 285.6 ± 5.6 | 288.0 ± 25.4 |
| LVEDP, mmHg | 4.5 ± 0.4 | 13.6 ± 2.3* | 3.1 ± 0.8 | 11.8 ± 2.2 |
| RSNA, ∝V·s | 3.4 ± 0.5 | 4.1 ± 0.6* | 2.6 ± 0.8‡ | 2.7 ± 0.1† |
| dP/dtmax, mmHg/s | 6,537.5 ± 608.5 | 4,284.2 ± 333.4* | 6,993.4 ± 974.8 | 5,868.8 ± 211.9† |
| dP/dtmin, mmHg/s | −5,871.8 ± 563.8 | −4,028.6 ± 169.1* | −6,419.4 ± 978.5 | −4,543.6 ± 261.8 |
Values are means ± SE; n = 5 rats/group. RSNA, renal sympathetic nerve activity.
*
P < 0.05 vs. the sham-LV-GFP group;
†
P < 0.05 vs. the CHF-LV-GFP group;
‡
P = 0.09 vs. the sham-LV-GFP group.