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. 2018 Oct;367(1):168–183. doi: 10.1124/jpet.118.251959

TABLE 1.

Pharmacodynamic parameters for genes fitted by model A

No. Gene Name Symbol kd,mRNA
SDRn(mRNA)
kd,protein
γ
Estimate %CV Estimate %CV Estimate %CV Estimate %CV
h–1 fmol/mg h–1
1 26S Proteasome regulatory subunit 8 Pscm5 0.24 66 0.001 45 0.54 122 1.4 43
2 40S Ribosomal protein S5 Rs5 0.33 66 0.001 40 1.1 159 1.9 33
3 40S Ribosomal protein S7 Rs7 0.16 55 0.001 38 1.2 156 2.4 28
4 60S Ribosomal protein l23a Rl23a 0.09 54 0.003 49 0.35 218 0.5 78
5 60S Ribosomal protein L3 Rl3 0.17 59 0.001 43 0.65 120 1.9 31
6 ADP ribosylation factor 4 Arf4 0.82 30 0.002 18 0.32 51 1.0 Fixed
7 Argininosuccinate lyase Asl 0.74 30 0.003 19 0.05 141 0.7 105
8 Argininosuccinate synthase 1 Ass1 0.06 40 0.008 42 0.027 61 3.3 34
9 Aspartate aminotransferase Got1 0.34 37 0.006 14 0.024 57 2.1 21
10 Aspartate–tRNA ligase, cytoplasmic Sdac 0.49 52 0.001 26 0.10 45 3.8 28
11 Aspartyl-tRNA Synthetase Dars 0.37 60 0.001 33 0.81 123 1.6 36
12 CCAAT-binding transcription factor i Ybx1 0.07 34 0.005 32 0.1 54 1.5 27
13 Cytochrome P450 27A1 Cyp27a1 0.12 48 0.002 38 0.58 98 1.0 28
14 Cytochrome P450 reductase Por 0.11 32 0.008 30 0.036 55 1.8 31
15 Galectin-9 Leg9 0.07 30 0.007 30 0.019 57 3.9 28
16 Heat Shock 70 kDa protein 5 Hspa5 0.90 42 0.001 15 0.3 Fixed 0.4 53
17 Heat shock cognate 71 kDa protein Hspa8 0.19 50 0.002 35 0.04 97 1.5 60
18 Heat shock protein d (hsp60) 1 Hspd1 0.10 38 0.003 32 0.06 98 0.7 67
19 Karyopherin subunit beta 1 Kpnb1 0.20 31 0.003 24 0.3 Fixed 0.6 36
20 NADPH:P450 oxidoreductase Ncpr 0.10 38 0.007 26 0.045 56 1.7 27
21 Nucleolin Ncl 0.40 38 0.004 17 0.06 44 1.0 Fixed
22 Nucleophosmin Npm 0.28 29 0.006 10 0.041 51 1.4 21
23 Oligosaccharyltransferase subunit 48 Ddost 0.46 37 0.001 21 0.3 Fixed 1.0 Fixed
24 Phosphoglucomutase-1 Pgm1 1.56 37 0.002 16 0.3 Fixed 0.2 59
25 Proteasome 26S subunit, ATPase 2 Psmc2 0.27 43 0.002 27 0.10 183 0.7 107
26 Ribosomal protein l4 Rpl4 0.20 50 0.001 32 0.07 61 2.1 35
27 Signal activator of transcription 3 Stat3 0.33 24 0.005 11 0.12 22 1.9 9.3
28 Tryptophan di-oxygenase Tdo2 0.16 25 0.004 21 1.5 65 2.0 15
29 Tubulin alpha 1 Tuba1c 0.09 49 0.004 45 0.3 Fixed 0.2 175
30 Tubulin beta 4b class iv Tubb4b 0.07 43 0.004 41 0.023 123 1.8 84
31 Tudor domain-containing protein 11 Snd1 0.14 54 0.001 40 0.031 96 2.3 64
32 Tyrosine aminotransferase Tat 0.26 55 0.002 34 0.17 50 5.0 26