TABLE 2.
Pharmacodynamic parameters for genes fitted by model B
| No. | Gene Name | Symbol |
kd,mRNA |
IC50, DRn(mRNA) |
kd,protein |
γ |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| Estimate | %CV | Estimate | %CV | Estimate | %CV | Estimate | %CV | |||
| h−1 | fmol/mg | h−1 | ||||||||
| 1 | Alanine–glyoxylate aminotransferase 2 | Agxt2 | 0.13 | 15 | 130.7 | 28 | 0.074 | 36 | 1.0 | Fixed |
| 2 | Aldehyde dehydrogenase 1A7 | Aldh1a7 | 0.50 | 85 | 622.0 | 46 | 0.3 | Fixed | 1.0 | Fixed |
| 3 | Amine oxidase A | Maoa | 0.90 | 18 | 587.2 | 7 | 0.013 | 63 | 1.0 | Fixed |
| 4 | Carboxylesterase 1E | Ces1e | 0.41 | 33 | 272.8 | 25 | 0.033 | 31 | 5.0 | Fixed |
| 5 | Cytochrome P450 2C18 | Cyp2c18 | 0.50 | Fixed | 416.8 | 17 | 0.018 | 43 | 5.0 | Fixed |
| 6 | Glutathione peroxidase 1 | Gpx1 | 1.50 | 50 | 779.4 | 21 | 0.020 | 88 | 1.1 | 7 |
| 7 | Murinoglobulin-1 | Mug1/2 | 0.24 | 27 | 164.6 | 34 | 0.038 | 35 | 5.0 | Fixed |