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. 2018 Oct;367(1):168–183. doi: 10.1124/jpet.118.251959

TABLE 2.

Pharmacodynamic parameters for genes fitted by model B

No. Gene Name Symbol kd,mRNA
IC50, DRn(mRNA)
kd,protein
γ
Estimate %CV Estimate %CV Estimate %CV Estimate %CV
h−1 fmol/mg h−1
1 Alanine–glyoxylate aminotransferase 2 Agxt2 0.13 15 130.7 28 0.074 36 1.0 Fixed
2 Aldehyde dehydrogenase 1A7 Aldh1a7 0.50 85 622.0 46 0.3 Fixed 1.0 Fixed
3 Amine oxidase A Maoa 0.90 18 587.2 7 0.013 63 1.0 Fixed
4 Carboxylesterase 1E Ces1e 0.41 33 272.8 25 0.033 31 5.0 Fixed
5 Cytochrome P450 2C18 Cyp2c18 0.50 Fixed 416.8 17 0.018 43 5.0 Fixed
6 Glutathione peroxidase 1 Gpx1 1.50 50 779.4 21 0.020 88 1.1 7
7 Murinoglobulin-1 Mug1/2 0.24 27 164.6 34 0.038 35 5.0 Fixed