TABLE 5.
Pharmacodynamic parameters for genes fitted by model E
| No. | Gene Name | Symbol |
kSR |
IC50, SR(mRNA) |
kd,mRNA |
IC50, DRn(mRNA) |
kd,protein |
γ |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Est | %CV | Est | %CV | Est | %CV | Est | %CV | Est | %CV | Est | %CV | |||
| h−1 | fmol/mg | h−1 | fmol/mg | h−1 | ||||||||||
| 1 | Adenosine kinase | Adk | 0.32 | 94 | 154.6 | 75 | 1.4 | 42 | 369.2 | 120 | 0.02 | 116 | 1.0 | Fixed |
| 2 | Arginase 1 | Arg1 | 0.14 | 76 | 76.3 | 47 | 2.8 | 35 | 162.0 | 79 | 0.01 | 93 | 1.0 | Fixed |
| 3 | Cystathionine-beta-synthase | Cbs | 0.19 | 71 | 191.5 | 31 | 1.1 | 69 | 799.6 | 79 | 0.1 | 73 | 1.5 | 46 |
| 4 | Heat shock protein HSP 90-beta | Hsp90ab1 | 0.07 | 72 | 274.0 | 52 | 2.1 | 207 | 4063 | 135 | 0.04 | 115 | 1.0 | Fixed |
| 5 | Sulfotransferase 1A1 | Sult1a1 | 0.17 | 43 | 54.0 | 39 | 2.4 | 19 | 154.7 | 55 | 0.03 | 47 | 1.0 | Fixed |
Est, estimate.