Fig. 6.

A box-and-whisker plot summarizes the optimization residual Lc.F_opt values for each group, indicating the wide variation in the GIO group compared to the SHAM group, and the significant difference in their distributions. The mean value and standard deviation is indicated above each boxplot. The dotted lines extend to the outliers beyond 1.5 times the interquartile range from the mean. The Wilcoxon-Mann-Whitney test yields p = 0.0046 for these two distributions. INSET: An illustration of the ellipsoidal fitting: the dotted line represents a section of the fitted ellipsoid; the solid line represents the lacuna surface. The departure from ellipsoidal is quantified by $\mathrm{Lc}.{\mathrm{F}}_{\mathrm{opt}}=\sqrt{\sum _{\mathrm{i}}{\left({\overline{\mathrm{AB}}}_{\mathrm{i}}\right)}^2/\mathrm{N}}$ where $\overline{\mathrm{AB}}$ is the distance between the best-fit ellipsoid at A and the surface voxel B in the direction toward the center C, and N is the total number of surface points.