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Decrease in resting state functional connectivity (rs-fc) from locus coeruleus (LC) to the thalamus following ketamine (p = .008, FWE cluster level corrected, cluster size = 252, Panel 1). Change in rs-fc between LC seed and thalamus in ketamine and placebo groups at baseline and 1 h after administration. Decrease of rs-fc is only significant in the ketamine group (p = .008, FWE cluster level corrected, Panel 2).
