Table 1.
Transposition patients compared to healthy controls
| TGA (N=53) | Controls (N=22) | P | |
|---|---|---|---|
| Age (years) | 34.6 ± 10.3 | 40.2 ± 11.3 | 0.0422 |
| Female | 22 (42%) | 9 (41%) | 0.94 |
| Height (in) | 67.3 ± 4.1 | 66.8 ± 4.3 | 0.65 |
| Weight (kg) | 85.8 ± 17.0 | 72.5 ± 14.3 | 0.002 |
| BSA (m2) | 1.97 ± 0.21 | 1.83 ± 0.22 | 0.011 |
| Hemoglobin (g/dl) | 14.5 ± 1.16 | 14.1 ± 1.2 | 0.21 |
| Hematocrit (%) | 42.2 ± 3.1 | 41.4 ± 3.4 | 0.13 |
| Sodium (mmol/l) | 139 ± 2 | 139 ± 2 | 0.30 |
| BUN (mg/dl) | 14.2 ± 4.0 | 12.8 ± 4.8 | 0.19 |
| Creatinine (mg/dl) | 0.82 ± 0.16 | 0.90 ± 0.11 | 0.068 |
| 6-minute walk distance (m) | 480 ± 117 | 639 ± 79 | <0.001 |
| CMR Findings | |||
| Systemic EDVi (ml/m2) | 102 ± 27 | 80 ± 25 | <0.001 |
| Systemic ESVi (ml/m2) | 52 ± 25 | 25 ± 6 | <0.001 |
| Pulmonic EDVi (ml/m2) | 81 ± 22 | 88 ± 14 | 0.16 |
| Pulmonic ESVi (ml/m2) | 34 ± 16 | 34 ± 8 | 0.99 |
| RV ejection fraction (%) | 52% ± 11% | 69% ± 6% | <0.001 |
| LV ejection fraction (%) | 59% ± 9% | 62 ± 56 | <0.001 |
| 15 min post contrast T1 (ms) | 397 ± 110 | 508 ± 45 | <0.001 |
| Lambda | 0.495 ± 0.070 | 0.445 ± 0.041 | 0.002 |
| ECV (%) | 28.7% ± 4.5% | 26.1% ± 2.8% | 0.010 |
| Biomarker Analysis | |||
| b-type natriuretic peptide (pg/ml) | 94 [162] | 19.5 [18] | 0.012 |
| ln BNP | 4.69 ± 1.17 | 2.92 ± 0.61 | <0.001 |
| Aldosterone (pg/ml) | 179 ± 95 | 181 ± 67 | 0.94 |
| PC1NP (pg/l) | 53.6 ± 23.7 | 44.7 ± 16.6 | 0.11 |
| PC3NP (pg/l) | 4.4 ± 2.1 | 2.8 ± 0.6 | 0.001 |
| TIMP-1(ng/ml) | 146 ± 31 | 130 ± 27 | 0.033 |
| MMP-2 (ng/ml) | 244 ± 53 | 182 ± 28 | <0.001 |
| MMP2/TIMP1 ratio | 1.71 ± 0.35 | 1.48 ± 0.42 | 0.021 |
Values are given as N (%), mean±SD, or median [interquartile range]. LV = left ventricular, RV = right ventricular, ECV = extracellular volume fraction. Lambda is the partition coefficient of gadolinium. PC1NP = procollagen 1 N terminal peptide, PC3NP = procollagen 3 N terminal peptide, MMP-2 = matrix metalloproteinase 2, TIMP-1 = tissue inhibitor of matrix metalloproteinase-1.