Table 3.
Comparison of baseline variables between subject with or without a major outcome event.
| Variable | No Event N=38 |
Event N=14 |
P |
|---|---|---|---|
| N=38 | |||
| Age (years) | 32.7 ± 9.8 | 39.4 ± 10.7 | 0.038 |
| Female | 17 (45%) | 4 (29%) | 0.29 |
| ECV (%) | 27.6 ± 3.5 | 31.8 ± 5.3 | 0.002 |
| Elevated ECV | 7 (18%) | 8 (57%) | 0.005 |
| Lambda | 0.479 ± 0.056 | 0.543 ± 0.085 | 0.003 |
| Native T1 (ms) | 952 ± 183 | 984 ± 235 | 0.61 |
| Post contrast T1 (ms) | 425 ± 110 | 316 ± 67 | 0.001 |
| Hematocrit (%) | 42.3 ± 3.2 | 41.6 ± 3.1 | 0.49 |
| Congenitally-corrected TGA | 6 (16%) | 3 (21%) | 0.63 |
| Prior atrial arrhythmia | 11 (29%) | 6 (43%) | 0.34 |
| Beta blocker use | 9 (24%) | 2 (14%) | 0.46 |
| ACEi/ARB use | 9 (24%) | 6 (43%) | 0.18 |
| Aldosterone inhibitor use | 1 (3%) | 2 (14%) | 0.11 |
| Loop diuretic use | 8 (21%) | 5 (36%) | 0.28 |
| QRS duration (ms) | 99 ± 40 | 108 ± 11 | 0.57 |
| Baseline heart rate (bpm) | 69 ± 14 | 76 ± 16 | 0.12 |
| Baseline O2 saturation (%) | 97 ± 2 | 96 ± 3 | 0.29 |
| Systolic blood pressure (mmHg) | 122 ± 11 | 115 ± 10 | 0.051 |
| 6MWT post heart rate (bpm) | 105 ± 26 | 104 ± 22 | 0.89 |
| 6MWT post O2 saturation (%) | 96 ± 4 | 91 ± 5 | 0.007 |
| 6MWT distance (m) | 484 ± 120 | 471 ± 111 | 0.76 |
| Body surface area (m2) | 1.97 ± 0.22 | 1.96 ± 0.23 | 0.73 |
| RVEDVi (ml/m2) | 99 ± 25 | 112 ± 31 | 0.18 |
| RVESVi (ml/m2) | 47 ± 20 | 66 ± 32 | 0.013 |
| RVEF (%) | 54 ± 9 | 43 ± 11 | 0.002 |
| Moderate-severe TR | 9 (24%) | 5 (36%) | 0.39 |
| RV mass index (g/m2) | 88.1 ± 19.7 | 91.5 ± 19.6 | 0.62 |
| LGE present | 6 (16%) | 1 (7%) | 0.43 |
| Sodium (mmol/l) | 139 ± 2 | 137 ± 2 | 0.002 |
| Creatinine (mg/dl) | 0.83 ± 0.16 | 0.85 ± 0.13 | 0.53 |
| ln BNP | 4.48 ± 1.07 | 5.23 ± 1.34 | 0.047 |
Values are given as N (%), mean±SD, or median [interquartile range]. TGA = transposition of the great arteries. ECV = extracellular volume fraction. Lambda is the partition coefficient of gadolinium. ACEi= angiotensin converting enzyme inhibitor. ARB = angiotensin receptor blocker. 6MWT = six-minute walk test. RVEDVi = RV end-diastolic volume index, RVESVi = RV end-systolic volume index. BNP = b-type natriuretic peptide.