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. 2018 Sep 19;38(38):8160–8176. doi: 10.1523/JNEUROSCI.0536-18.2018

Figure 5.

Figure 5.

sphk-1 mutants block SKN-1-mediated aldicarb resistance. Rates of aldicarb-induced paralysis of indicated strains following exposure to arsenite (As). A, Wild-type (wt) animals treated with arsenite were resistant to the paralytic effects of aldicarb. sphk-1 mutants were resistant to aldicarb but exhibited sensitivity to aldicarb when exposed to arsenite. B, Knock-down of wdr-23 by RNAi increased the aldicarb resistance in wild-type controls but not in sphk-1 mutants. C, Ability of constitutively active skn-1(lax188gf) mutation to cause aldicarb resistance was blocked by sphk-1 mutants. D, Overexpression of pmk-1 cDNA in the intestine of pmk-1 mutants caused aldicarb resistance in sphk-1(+) but not sphk-1(null) background. E, Percentage of wild-type and sphk-1 mutants paralyzed by aldicarb after 110 min following 4 h treatment with juglone and paraquat. Numbers of animals tested are indicated. Error bars indicate ± SEM. Student's t test, *p < 0.05, **p < 0.01, ***p < 0.001.