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. 2018 Sep 20;15:272. doi: 10.1186/s12974-018-1305-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic representation of the experimental design for the rat PGJ2-treatment. Eighteen-week-old male Sprague Dawley male rats were microinjected into the right SNpc as shown. Rats received two or four microinfusions of either DMSO (control; 17% in PBS) or PGJ2 (33.4 μg) in 2 μL DMSO/PBS at weekly intervals. Ibuprofen (IBP)-treated rats were fed IBP-mixed chow (800 ppm, ~ 40 mg/kg body weight) starting the day after the first microinfusion and ending 5 weeks later. For all rats, motor behavior was assessed before the first injection and 4 weeks or 8 weeks after the last injection. Following post-injection behavioral assessment, rats were perfused intracardially and the brains were removed for immunohistochemical analyses. N = number of rats per group (gp). X = number of injections (once per week)