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. 2018 Sep 20;15:272. doi: 10.1186/s12974-018-1305-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Correlation between behavioral deficits and dopaminergic (TH+) neuronal loss in the SNpc induced by successive PGJ2 microinfusions. a All groups of rats treated with PGJ2 (shades of red circles) exhibited behavioral deficits. When compared to DMSO-treated rats (white, gray and black circles), those treated with 2X and 4X PGJ2 significantly increased usage of the ipsilateral forelimb as assessed by the cylinder test (see Materials and Methods). Statistical significance was estimated with the Student’s T test to compare DMSO and PGJ2-treated groups, and between two PGJ2-treated groups. The p values in red indicate the values that are significantly (< 0.05) different from DMSO-injected rats. N = 4 to 8 rats per group. b In the PGJ2-treated but not in the control (DMSO) rats, dopaminergic neuronal loss (TH+) in the ipsilateral SNpc (x-axis) inversely correlates with forelimb usage asymmetry (y-axis). X = number of injections (once per week)