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. 2018 Sep 20;15:272. doi: 10.1186/s12974-018-1305-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Successive PGJ2 microinfusions induce aggregate-like ubiquitinated protein (a) and pS129 α-synuclein (b) deposits in dopaminergic neurons. Immunostaining for ubiquitinated proteins (red in a), pS129 α-synuclein (red in b), and TH+ neurons (blue in a and b) at 4 weeks after two (2X) and four (4X) PGJ2 microinjections. Dopaminergic neurons in the SNpc of PGJ2-treated rats exhibit aggregate-like ubiquitin conjugates and pS129 α-synuclein neuronal inclusions (white arrows). Scale bar = 50 μm. c Values on the y-axis represent the optical density (OD) ratios between ipsilateral SNpc over the contralateral, normalized to the TH+ signal. Black circles, control, DMSO-treated rats; red circles, PGJ2-treated rats. Statistical significance was estimated with the Student’s T test to compare DMSO and PGJ2-treated groups. The p value in red indicates significant (p < 0.05) difference from DMSO-injected rats. N = 3 rats per group. X = number of injections (once per week)