FIG 2.

Impact of the VP5 mutations on plaque size. Vero cells were infected with VP5 apical region mutants (A) and additional VP5 glutamic acid mutants (B). Plaque diameters were measured 5 days postinfection. Diameters are represented as a percentage of the mean plaque diameter of wild-type HSV-1 strain F (WT). Repaired alleles are listed as E846A>E and E851A>E. Error bars indicate the standard deviations from three independent experiments. Asterisks indicate a statistically significant difference from the WT or VP5 EE>AA, as determined by Tukey's multiple-comparison test (****, P ≤ 0.0001).