FIG 2.
Deletion of the 135 gene results in less attenuation than that with deletion of the tk gene for GTPV in sheep. Sheep were inoculated intradermally with the AV41, Δ135, or Δtk virus. (A) Diameters of lesions at inoculation sites in sheep that received 105.0 TCID50 (I) and 106.0 TCID50 (II) were measured and recorded every day. (B) Representative lesions are shown for day 6 after inoculation (I), and the significance of differences in diameters between viruses was determined using the t test (II). *, P < 0.05; **, P < 0.01.