Mean diversity of E1/E2 variants in adult horses that cleared infection (H1, H2, and H3), persistently infected foals (foals 1 and 2), persistently infected adult horses (horses 753, 755, and 757), and SCID foals 1 and 2. Genetic diversity was determined by calculating the mean Hamming distance of the predicted amino acid sequences of all variants detected in each group. Error bars represent the standard errors of the means. Asterisks indicate significant differences (*, P = 0.0016; **, P < 0.0005) as determined by one-way ANOVA, with Tukey's posttest for multiple comparisons.