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Induction of disease in the M83+/− αS transgenic mouse model following unilateral sciatic nerve injections. Kaplan-Meier curves reveal the transmissibility of the indicated recombinant proteins following unilateral sciatic nerve injection in the M83+/− line of αS transgenic mice. Mice were injected with mouse WT αS fibs (mfib αS), E46K human αS fibs (hfib αS E46K), human Δ71–82 αS, recombinant WT SOD1 fibrils, or PBS.
