FIG 12.

Inability of mouse αS fibs to induce αS pathology in WT mice. WT mice were injected unilaterally in the sciatic nerve with mouse WT αS fibs (mfib αS) (a) or PBS (b) and harvested at 12 months p.i. (n ≥ 6 animals per cohort). Representative images show the lack of αS pathology in both the ipsilateral and contralateral DRG and several CNS regions, depicted by cartoons with black dots representing the specific locations the images were taken. Tissue sections were stained with an antibody to αS phosphorylated at Ser129 (2G12) and counterstained with hematoxylin. Scale bars = 50 μm.