FIG 4.

Absence of αS inclusion pathology in M83^+/− mice injected with control inocula. Mice were injected unilaterally in the sciatic nerve with PBS (a), soluble human αS containing Δ71–82 (b), or WT SOD1 fibs (c) and aged to 6 months p.i. prior to harvesting tissue (n = 6 animals per cohort). Representative images show αS pathology in both the ipsilateral and contralateral DRG and several CNS regions, depicted by cartoons with black dots representing the specific locations the images were taken. Tissue sections were stained with an antibody to αS phosphorylated at Ser129 (2G12) and counterstained with hematoxylin. Scale bars = 50 μm.