FIG 8.

Induction and spread of αS pathology in the M20^+/− mouse model following injection with mouse αS fibs. Mice were injected unilaterally in the sciatic nerve with mouse WT αS fibs (mfib αS) and harvested at 2 months (a) or 4 months (b) p.i. or when the mice reached the end stage of disease (c) (n ≥ 8 animals per cohort). Representative images show αS pathology in both the ipsilateral and contralateral DRG and several CNS regions, depicted by cartoons with black dots representing the specific locations the images were taken. Tissue sections were stained with an antibody to αS phosphorylated at Ser129 (2G12) and counterstained with hematoxylin. Scale bars = 50 μm.