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αS inclusion pathology in M20+/− injected mice. M20+/− mice were injected unilaterally in the sciatic nerve with the indicated homogenates and harvested at the end stage of disease (mfib αS) or at 12 months p.i. (PBS, Δ71–82 αS, and WT SOD1 fibs). Spinal cords were stained with a conformation-specific antibody against αS, Syn 506 (a), and an antibody specific for cytoplasmic Lewy body inclusions, p62/Sqstm1 (b).
