TABLE 1.
Spatiotemporal distribution and abundance of αS pathology in M83+/− mice following sciatic nerve inoculation with mouse WT αS fibs
| Body site | Relative abundance of αS inclusion pathologya |
||
|---|---|---|---|
| 1 mo p.i. | 2 mo p.i. | Clinical (3.9 ± 0.1 mo p.i.) | |
| DRG | |||
| Ipsilateral | + | ++ | ++ |
| Contralateral | − | − | + |
| Spinal cord | |||
| Lumbar | + | ++ | +++ |
| Thoracic | − | + | +++ |
| Cervical | − | − | +++ |
| Brain | − | ||
| Reticular formation | − | ++ | +++ |
| Lateral vestibular nucleus | − | − | ++ |
| Red nucleus | − | + | +++ |
| PAG | − | + | +++ |
| Motor cortex | − | − | + |
a
−, none; +, rare; ++, numerous; +++, abundant and widespread.