TABLE 2.
Spatiotemporal distribution and abundance of αS pathology in M20+/− mice following sciatic nerve inoculation with mouse WT αS fibs
| Body site | Relative abundance of αS inclusion pathologya |
||
|---|---|---|---|
| 2 mo p.i. | 4 mo p.i. | Clinical (8.3 ± 0.6 mo p.i.) | |
| DRG | |||
| Ipsilateral | − | − | + |
| Contralateral | − | − | − |
| Spinal cord | |||
| Lumbar | + | ++ | +++ |
| Thoracic | − | + | +++ |
| Cervical | − | − | +++ |
| Brain | |||
| Reticular formation | − | + | +++ |
| Lateral vestibular nucleus | − | − | ++ |
| Red nucleus | − | + | +++ |
| PAG | − | + | +++ |
| Motor cortex | − | − | − |
a
−, none; +, rare; ++, numerous; +++, abundant and widespread.