FIG 12.

Effects of mutation(s) in UL51 on the mortality of mice following intracranial or ocular infection. (A) Three-week-old female mice were inoculated intracranially with serial 10-fold dilutions of the indicated viruses in groups of 6 per dilution and were monitored for 14 days. LD₅₀ values were determined by the Behrens-Karber method. (B) Forty-five 3-week-old female ICR mice were infected ocularly with 1 × 10⁶ PFU/eye of each virus and were monitored for 14 days. Differences in the mortality of infected mice were statistically analyzed by the log-rank test, and for three comparison analyses, P values of <0.0167 (0.05/3), <0.025 (0.05/2), or <0.05 (0.05/1) were sequentially considered significant after Holm's sequentially rejective Bonferroni multiple-comparison adjustment.