Table 1.
Demografic and biochemical data
| Unit | Sham + placebo | Sham + losartan | BDL + placebo | BDL + losartan | |
|---|---|---|---|---|---|
| Initial number rats | N | 8 | 8 | 10 | 10 |
| Mortality | N | 0 | 0 | 3 | 6 |
| Rats with/ without ascites | N | 0\8 | 0\8 | 7\1 | 3\3 |
| Preoperative weight | g | 237 ± 5 | 243 ± 9 | 240 ± 4 | 237 ± 7 |
| Final weight | g | 346 ± 14 | 366 ± 15 | 325 ± 5 | 317 ± 9 |
| Final weight (dry) | g | 346 ± 14 | 366 ± 15 | 317 ± 6 | 314 ± 8 |
| Weight gain (dry) | g | 109 ± 13† | 123 ± 12† | 77 ± 5 | 77 ± 8 |
| Liver | (g/100gBW) | 3.37 ± 0.17††† | 3.31 ± 0.05††† | 7.41 ± 0.37 | 7.09 ± 0.22 |
| Spleen | (g/100gBW) | 0.19 ± 0.01††† | 0.19 ± 0.004††† | 0.62 ± 0.02 | 0.50 ± 0.05* |
| Kidney | (g/100gBW) | 0.56 ± 0.08†† | 0.60 ± 0.01† | 0.76 ± 0.01 | 0.80 ± 0.03 |
| Heart | (g/100GBW) | 0.27 ± 0.01† | 0.25 ± 0.01†† | 0.33 ± 0.02 | 0.28 ± 0.02 |
| Adrenal gland | (g/100gBW) | 0.016 ± 0.001 | 0.015 ± 0.001 | 0.018 ± 0.001 | 0.018 ± 0.001 |
| B-Haemoglobin | mmol/L | 9.7 ± 0.1 | 9.7 ± 0.1 | 9.6 ± 0.4 | 9.9 ± 0.6 |
| B-Haematocrit | % | 47 ± 1 | 46 ± 1 | 49 ± 1 | 49 ± 3 |
| B-Leucocytes | 10*9/L | 5.8 ± 0.4††† | 6.3 ± 0.3††† | 26.0 ± 2.3 | 23.9 ± 4.7 |
| B-Platelets | 10*9/L | 791 ± 33 | 769 ± 41 | 567 ± 113 | 597 ± 56 |
| S-Bilirubin | μmol/l | 1.3 ± 0.16††† | 0.8 ± 0.17††† | 188.6 ± 10.8 | 227.3 ± 18.6 |
| S-Albumin | μmol/l | 667.3 ± 35.7††† | 607.6 ± 23.1† | 475.0 ± 25.2 | 514.8 ± 18.4 |
| S-Creatinine | μmol/l | 17.6 ± 0.6 | 16.3 ± 2.1 | 18.3 ± 1.3 | 21.5 ± 2.6 |
| P-Osmolality | mOsm/kg | 305 ± 2 | 306 ± 2 | 300 ± 1 | 304 ± 2 |
| P-Sodium | mmol/l | 139 ± 1.0 | 139 ± 0.8 | 141 ± 0.4 | 140 ± 0.9 |
| P-Potassium | mmol/l | 6.3 ± 0.2 | 6.5 ± 0.4 | 5.8 ± 0.2 | 7.1 ± 0.5* |
Values are given as mean ± SEM. *p < 0.05: BDL placebo vs. BDL losartan. †p < 0.05: Sham vs. BDL, ††p < 0.01 Sham vs. BDL, †††p < 0.001: Sham vs. BDL