Table 2.

Univariate and multivariate logistic regression analysis for the associated risk factors for developing bone metastases in patients diagnosed with uterine cervical cancer between 2010–2015.

Subject characteristics	Univariate analysis		Multivariate analysis
	OR (95% CI)	P-value	OR (95% CI)	P-value
Age (years)
≤40	1 (Reference)	1.00	1 (Reference)	1.00
41–64	2.63 (1.98–3.51)	<0.001	1.44 (0.95–2.18)	0.08
≥65	3.34 (2.44–4.58)	<0.001	1.36 (0.84–2.21)	0.22
Marital status
Married	1 (Reference)	1.00	1 (Reference)	1.00
Unmarried	1.29 (1.06–1.56)	0.01	0.99 (0.74–1.33)	0.94
Unknown	NA	NA	NA	NA
T-stage
T1	1 (Reference)	1.00	1 (Reference)	1.00
T2	3.34 (2.40–4.65)	<0.001	1.97 (1.25–3.10)	0.003
T3	10.71 (8.00–14.32)	<0.001	3.86 (2.52–5.91)	<0.001
T4	14.69 (10.20–21.15)	<0.001	4.05 (2.36–6.96)	0.001
Unknown	NA	NA	NA	NA
N-stage
N0	1 (Reference)	1.00	1 (Reference)	1.00
N1	7.20 (5.80–8.94)	<0.001	2.89 (2.09–4.00)	<0.001
Unknown	NA	NA	NA	NA
Histology
Squamous	1 (Reference)	1.00	1 (Reference)	1.00
Adenocarcinoma*	0.80 (0.63–1.02)	0.07	1.17 (0.81–1.69)	0.40
Others	2.93 (2.33–3.67)	<0.001	1.87 (1.24–2.82)	0.003
Grade
I	1 (Reference)	1.00	1 (Reference)	1.00
II	3.12 (1.56–6.24)	0.001	1.66 (0.73–3.77)	0.23
III#	8.68 (4.45–16.95)	<0.001	2.72 (1.23–6.04)	0.01
Unknown	NA	NA	NA	NA
Lung metastases
None	1 (Reference)	1.00	1 (Reference)	1.00
Yes	20.16 (16.44–24.72)	<0.001	5.00 (3.54–7.06)	<0.001
Unknown	NA	NA	NA	NA
Liver metastases
None	1 (Reference)	1.00	1 (Reference)	1.00
Yes	25.36 (20.04–32.09)	<0.001	6.25 (4.10–9.54)	<0.001
Unknown	NA	NA	NA	NA
Brain metastases
None	1 (Reference)	1.00	1 (Reference)	1.00
Yes	27.83 (17.44–44.36)	<0.001	7.21 (3.10–16.74)	<0.001
Unknown	NA	NA	NA	NA

^*Including adenosquamous;

^#including undifferentiated;

NA – not available. All factors with unknown data were removed from the univariate and multivariate logistic regression model.