Table 2.

Candidate genes from potentially enriched ontologies with putative functional link to minipigs

Gene name	Function	Reference
ACACB	Downregulated by TGFB1; influencing type-II-diabetes; obesity and lipid metabolism	Zhou et al. [87]; Ma et al. [88]
ACOT4	Linked to FGF21 in mice	Muise et al. [89]
ADAMTS12	Blocks Ras/ MAPK pathway	Llamazares et al. [90]
COMT	Reduced birth weight in humans	Sata et al. [33]
DUSP28	Activator of MAPK pathway	Wang et al. [91]
HYAL1, HYAL2	Overexpressed in the placenta of the smallest pig fetuses	Vallet et al. [92]
LTBP1	TGFB signaling, role in the regulation of human height	Lango Allen et al. [31]
MAGOH	Influences MAPK	Roignant and Treisman [93]
MAPK1	Coding central proteins ERK2 in the Ras/ MAPK	Reviewed by Cobb et al. [94]
NDUFB9	Severe growth-hormone deficiency	Riedl et al. [95]
OSM	Diabetes type II	Sanchez-Infantes et al. [96]
PATZ1	Null mice were retarded in growth, Homozygote animals were 10 to 20% smaller, than their litter mates of the same sex	Valentino et al. [34]
PKP2	Associates EGF	Kazlauskas [97]
PPARG	Muscle specific expression; deletion causes insulin resistance in mice; key role in pig growth; reduced size in pre-pubertal children	Crooks et al. [43]; Hevener et al. [42]; Puig-Oliveras et al. [44]; Cecil et al. [45]
PRKAR2A	Obesity and lipid metabolism	Park et al. 2012 [98]
PTPRR	Member of the MAPK pathway	Hendriks et al. [99]
SOD1	Depressor of the MAPK pathway central genes ERK1/2	Juarez et al. [100]