FIG 4.

Relationship between RT-integrase-mediated RC in early infection and markers of disease progression. (A) The RC of the recombinant viruses encoding RT-integrase derived from individuals with early HIV-1 C infection correlated negatively with subsequent viral load set point (P = 0.03 by Spearman's correlation). (B) Higher RC corresponds to a higher rate of CD4 decline. The regression lines show prediction of CD4 decline when RT-integrase RC is stratified by the median as RC of >0.92 (red) and RC of <0.92 (blue) (P < 0.001 by GEE model). The bars represent 95% confidence intervals. Sqrt, square root.