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Relationship between RT-integrase-mediated RC in chronic infection and markers of disease progression. The RC of NL4-3 recombinant viruses encoding RT-integrase derived from chronically HIV-1C-infected individuals correlated positively with the plasma log viral load (A) and negatively with the CD4 count (B). Pearson's (P < 0.0001) and Spearman's (P < 0.0001) correlations were used, respectively.
