FIG 7.

Relationships between HLA-associated polymorphisms in RT or integrase and RT-integrase-mediated RC in early infection. The number of RT HLA-associated polymorphisms correlated positively with RC (P = 0.05 by Spearman's correlation) (A), and the association was stronger when considering only those polymorphisms present in or adjacent to A list epitopes (P = 0.02 by Student's t test) (B). The number of integrase polymorphisms correlated negatively with RC (P = 0.024 by Spearman's correlation) (C), and the association was strengthened when limited to those polymorphisms present in or adjacent to A list epitopes (P < 0.0001 by ANOVA) (D). Counts were performed irrespective of the host HLA alleles.