TABLE 1.
Late genes regulated by AP-1(A/S)
Genea | Function | % activation by qPCRb |
% activation by RT-qPCRb | |
---|---|---|---|---|
Array 1 | Array 2 | |||
BBLF1 | MyrP | 347 | 100 | 124 |
BBRF1 | Portal protein, U16 homolog | 420 | 56 | 86 |
BBRF2 | Egress protein, UL7 homolog | 222 | 73 | 86 |
BDLF3 | gp150, immune evasion | 70 | 104 | 47 |
BGRF1 | Tripartite terminase subunit UL15 homolog | 109 | 90 | 158 |
BKRF2 | Envelope glycoprotein L | ND | 97 | 89 |
BKRF4 | Tegument protein | 400 | 113 | 84 |
BLLF3 | Deoxyuridine 5′ triphosphate nucleotidohydrolase | ND | 84 | 73 |
BLRF1 | Glycoprotein N | 426 | 88 | 119 |
BMRF2 | Viral attachment | 298 | 115 | 60 |
BRRF2 | Tegument protein | 700 | 164 | 104 |
BSRF1 | Tegument protein | 1176 | 169 | 72 |
All of these genes have previously been characterized as late genes in Akata cells treated with anti-IgG (38).
Activation was determined in BZKO cells. Values represent the ratio of activation by AP-1(A/S)/activation by ZEBRA. ND, not determined.