FIG 5.

Sex differences in antibody Fc-mediated functionality. Statistical correlations between gp120-targeted ADCP and ADCC only in vaccinated males (A), ADCML of SIV and gp120-targeted ADCP only in vaccinated females (B), and ADCML of SIV-infected cells and gp140-targeted ADCC only in vaccinated males (C) are shown. The animal cohorts are displayed within each graph heading, and the symbols represent values from individual macaques. Significant correlations, calculated using Spearman's rank correlation coefficient and adjusted for immunization group, are indicated by r and P values and linear regression trend lines (added for visual aid).