Scheme 1.
Scope of the divergent C(sp3)−H arylation on quinuclidine 3. Reagents and conditions: (1) picolinic acid, CDI, DMF, RT, 16 h; (2) ArI, Pd(OAc)2, Ag2CO3, DMF, 100 °C, 16 h. * A 1:1 mixture of diastereomers starting from (±)‐3.
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