Table 1.

In vivo activity of the racemic aryl analogues (±)‐15 b and (±)‐15 c and (−)‐quinine hydrochloride as a reference against P. berghei in mice.

Substance	Dose [mg/kg]	Parasitemia reduction [%][a]	Survival[b] [days]
(−)‐quinine hydrochloride	30	42	euthanized
	100	80	7±0
(±)‐15 b [c]	30	98	8±1
	100	99	21±7
(±)‐15 c [c]	30	0	euthanized
	100	98	7±1

[a] Blood for parasitemia determination was collected on day 3 (72 h after infection). [b] Mean survival time in days ± standard deviation. Mice with a parasitemia reduction <50 % were euthanized on day 3 post‐infection in order to prevent death, otherwise occurring on day 6. [c] Purity of >99 % determined by HPLC analysis.