Fig. 4.

Immunostaining for fibrinogen in the gray and white matter of AD subjects with CAA type 1, AD subjects with CAA type 2, AD subjects without CAA, and nondemented elderly subjects demonstrates increased vascular and parenchymal fibrinogen immunoreactivity in the white matter of (A) AD patients with CAA type 1 compared with (B) elderly controls. (C) Fibrinogen staining as mean ± SD, *p < 0.05. Abbreviations: AD, Alzheimer disease; CAA, cerebral amyloid angiopathy; WM, white matter, GM, gray matter.