Figure 3.

Redistribution of p300 after p53-Mediated Enhancement of p300 Autoacetylation

(A) Heatmaps depicting the enrichment of ac-p300, p300, H3K27ac, RNA Polymerase II (RNAPII), and H3K4me1 at promoters (TSS ±5 kb).

(B) Venn diagram showing the overlap between the up-regulated genes enriched at the promoters with both ac-p300 and p300 and genes unique to each set.

(C and D) ChIP-qPCR to determine the occupancy of (C) p53 and (D) autoacetylated p300 (Ac-p300) at p53-responsive gene promoters. (See Figure S2.)