Figure 2.

Changes in mRNA and Protein Abundance Correlate during Immortalization, but Not Following Ras Transformation

(Left) Fraction of total expressed genes whose mRNA (red) or protein (purple) significantly increased (solid) or decreased (striped) during (A) immortalization (IMO) or (B) transformation (TFO).

(Middle) Venn diagram of mRNAs and proteins that increased or decreased significantly (p < 0.05) during (A) immortalization or (B) transformation. Overlapping area represents genes for which both the mRNA and corresponding proteins changed in the same direction during the indicated transition.

(Right) Log2 fold change (L2FC) of RNA (x axis) plotted against the L2FC of the corresponding proteins (y axis) during (A) immortalization and (B) transformation. Red dots denote significant (p < 0.05) changes in RNA only, blue is protein only, and yellow indicates that both RNA and corresponding protein changed significantly.

See also Figures S2 and S3.