Figure 3.

ClinVar variants for Brugada syndrome by gene and clinical interpretation. A, All variants submitted to ClinVar (http://clinvar.com/) by clinical labs for Brugada syndrome have been plotted (N=1223, excluding 182 variants that were literature only or research). Genes are listed along the y axis, whereas the x axis shows the count of variants for each gene. Bars are color coded based on the clinical classification of variants (see legend). B, The relative proportion of submitted variant interpretation classifications for SCN5A and Limited evidence genes.