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Investigation of 17β-HSD1 inhibition reversibility of selected 13α-estrone compounds 9, 11a, 12a. Inhibitor compounds were preincubated with human placental cytosol. Following a 50-fold dilution step, the usual enzyme activity measurement was applied. Mean ± SD of three separate experiments. Experimental conditions: I No preincubation, 0.2 μM, II No preincubation, 10 μM, III Preincubation, 10 μM, 2.5 min, IV Preincubation, 10 μM, 20 min.
