Skip to main content
. 2018 Sep 19;33(1):1271–1282. doi: 10.1080/14756366.2018.1490731

Table 2.

Reference IC50 parameters of the substrate compounds. Relative conversions (Rel. conv., control incubation with no inhibition is 100%) measured in the presence of 10 μM concentration of the compound tested. Mean ± SD, n = 3.

Comp. Structure Arom STS 17β-HSD1
    IC50 ± SD (µM) IC50 ± SD (µM) IC50 ± SD (µM)
Testosterone (2) graphic file with name IENZ_A_1490731_ILG0001.gif 0.52 ± 0.14    
E1S (3) graphic file with name IENZ_A_1490731_ILG0002.gif   5.2 ± 1.2  
E1 (4) graphic file with name IENZ_A_1490731_ILG0003.gif >10 Rel. conv. 78 ± 7% 24 ± 10 0.63 ± 0.11

IC50: the inhibitor concentration decreasing the enzyme activity to 50%. Ki: inhibitor constant determined from Dixon plot; SD: standard deviation.