Table 3.

In vitro inhibition of enzyme activities by the test compounds.

		Arom		STS		17β-HSD1
Comp.	Structure	Rel.conv. ± SD (%)	IC50 ± SD (µM)	Rel.conv. ± SD (%)	IC50 ± SD (µM)	Rel.conv. ± SD (%)	IC50 ± SD (µM)
6a		62 ± 1		64 ± 3			0.064 ± 0.034
7a		88 ± 2			0.23 ± 0.09 Ki = 0.36 ± 0.05 μM		0.36 ± 0.25
8a		86 ± 6		80 ± 13		55 ± 7
6b			8.7 ± 2.8		2.0 ± 0.4		0.095 ± 0.031
7b		91 ± 6			0.89 ± 0.3		0.30 ± 0.20
8b		81 ± 5			2.1 ± 0.6		0.96 ± 0.45
6c			6.0 ± 1.2		2.4 ± 0.4		0.18 ± 0.02
7c		92 ± 3			1.6 ± 0.3		0.60 ± 0.16
8c		82 ± 4			3.0 ± 0.9		0.59 ± 0.16
9		85 ± 13		96 ± 1			1.2 ± 0.2 [12] Ki = 1.9 ± 0.2 μM
10a		82 ± 10		83 ± 3			0.59 ± 0.23 [13]
11a		90 ± 7			6.0 ± 1.6		1.0 ± 0.3 [13] Ki = 2.2 ± 0.3 μM
12a		91 ± 1			2.4 ± 0.5		0.38 ± 0.08 [13] Ki= 0.94 ± 0.15 μM
10b		100 ± 5		81 ± 6			1.2 ± 0.3 [13]
11b		78 ± 1			8.5 ± 3.1		2.1 ± 1.2 [13]
12b		108 ± 11		71 ± 4			2.7 ± 0.1 [13]
10c		106 ± 6		57 ± 1			0.33 ± 0.10
11c		98 ± 3		80 ± 7			2.6 ± 1.0
12c		101 ± 4		70 ± 3			2.2 ± 0.6
13		95 ± 12		76 ± 5			1.1 ± 0.33 Ki = 2.0 ± 0.4μM
14a		89 ± 9			3.9 ± 1.6		2.9 ± 1.6
15a		92 ± 7			2.7 ± 1.3	57 ± 9
16a		94 ± 2		59 ± 13		61 ± 7
14b		97 ± 5			4.1 ± 1.3		1.3 ± 0.8
15b		90 ± 8			3.7 ± 1.2	49 ± 12	11 ± 4
16b		82 ± 6			7.5 ± 2.0		4.1 ± 2.5
14c		88 ± 10			7.0 ± 1.9		2.6 ± 1.3
15c		89 ± 1			6.3 ± 1.8		4.5 ± 2.0
16c		82 ± 12			1.3 ± 0.4 Ki = 1.9 ± 0.2 μM	53 ± 2