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In vivo DOX biodistribution of free DOX, NGO/DOX@SPC, and NGO/DOX@SPC-FA after intravenous administration for the cervical tumour-bearing nude mice at 5 h (A) and 24 h (B). The tumour and normal organs were collected from the mice at 5 h and 24 h after administration, and then HPLC was used to analyze the accumulation of DOX in the tumour and normal organs. ***P＜0.001 versus their respective control. Data are presented as mean ±SD (n = 3)
