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Renal impairment was defined as glomerular filtration rate (GFR) < 90 mL/min/1.73 m2; CKD as GFR < 60 mL/min/1.73 m2 persisting from baseline to the 16th and/or the 24th week. P for association between GFR and TDF use at baseline, the 16th and the 24th week were 0.254, 0.038, and 0.027, respectively.
