Table 4.

ANOVA of repeated measures with pair-wise comparisons for urine parameters

Variable	Baseline vs. 16th wk		16th vs. 24th wk		Baseline vs. 24th wk		F	P value
	Mean diff.	P value	Mean diff.	P value	Mean diff.	P
TDF group
Phosphate	2.97	0.003	5.25	< 0.001	8.22	< 0.001	30.246	< 0.001
Glucose	0.08	0.173	0.17	0.013	0.25	< 0.001	4.269	0.017
Uric acid	50.90	< 0.001	91.67	< 0.001	142.58	< 0.001	20.837	< 0.001
Albumin	0.64	< 0.001	0.79	0.001	1.43	< 0.001	16.003	< 0.001
Creatinine	44.59	0.110	21.31	0.425	65.90	< 0.001	2.443	0.093
Total protein	2.54	0.007	−0.51	0.603	2.03	< 0.001	6.904	0.002
Non-TDF group
Phosphate	1.02	0.394	5.49	< 0.001	6.51	< 0.001	8.143	0.062
Glucose	0.14	0.008	−0.07	0.211	0.07	0.040	3.775	0.051
Uric acid	43.54	0.065	59.01	0.003	101.55	< 0.001	10.494	0.031
Albumin	0.51	< 0.001	0.67	0.014	1.18	< 0.001	25.281	0.001
Creatinine	14.04	0.601	9.97	0.493	34.01	0.230	1.083	0.342
Total protein	1.88	0.002	−0.68	0.355	2.56	0.083	3.147	0.047

Mean diff., difference between means; TDF, tenofovir disoproxil fumarate.