Table 1.
Author | Patient enrolled | Phase | Treatment regimes | Median age, years | Median PFS, months | No for analysis |
---|---|---|---|---|---|---|
Audeh et al, 201027 | 57 | II | Olaparib 400 mg bid | 54 | NR | 57 |
Gelmon et al, 201126 | 65 | II | Olaparib 400 mg bid | 58 | 7.1 | 65 |
Kaye et al, 201225 | 97 | II | Olaparib 200 mg bid | 58.5 | 6.5 | 64 |
Pegylated liposomal doxorubicin | 53 | 7.1 | 33 | |||
Ledermann et al, 201224 | 265 | II | Olaparib 400 mg bid po | 58 | 8.4 | 136 |
Placebo | 59 | 4.8 | 128 | |||
Liu et al, 201431 | 90 | II | Olaparib 400 mg bid po | 57.8 | 9 | 46 |
Coleman et al, 201530 | 50 | II | Veliparib 400 mg bid po | 57 | 8.18 | 50 |
Bell-McGuinn et al, 201629 | 12 | II | Iniparib 8 mg/kg | NR | NR | 12 |
Domchek et al, 201628 | 154 | II | Olaparib 400 mg bid po | 58 | NR | 154 |
Mirza et al, 201621 | 553 | III | Niraparib 300 mg qd po | 57 | 21 | 367 |
Placebo | 58 | 5.5 | 179 | |||
Pujade-Lauraine et al, 201723 | 295 | III | Olaparib 150 mg bid po | 56 | 19.1 | 195 |
Placebo | 56 | 5.5 | 99 | |||
Swisher et al, 201732 | 206 | II | Rucaparib 600 mg bid po | NR | NR | 206 |
Coleman et al, 201722 | 564 | III | Rucaparib 600 mg bid po | 61 | 16.6 | 375 |
Placebo | 62 | 5.4 | 189 |
Abbreviations: NR, not reported; PFS, progression-free survival; Bid, bis in die; Po, per os.