Table 2.
Incidence of adverse outcomes for clinical trials included in the meta-analysis
| Adverse outcome | Grade | Trials | Events | No of patients | Incidence, % (95% CI) | I2 |
|---|---|---|---|---|---|---|
| Nausea | All-grade | 12 | 1,225 | 1,727 | 68.8 (63.5–73.6) | 76 |
| Grade 3 and 4 | 12 | 53 | 1,727 | 3.4 (2.6–4.5) | 0 | |
| Vomiting | All-grade | 10 | 611 | 1,669 | 36.2 (30.9–41.8) | 76 |
| Grade 3 and 4 | 10 | 39 | 1,669 | 2.0 (1.4–3.0) | 0 | |
| Diarrhea | All-grade | 11 | 433 | 1,677 | 25.3 (21.2–29.8) | 70 |
| Grade 3 and 4 | 11 | 21 | 1,677 | 1.7 (1.0–3.0) | 38 | |
| Constipation | All-grade | 9 | 476 | 1,566 | 25.3 (17.9–34.5) | 92 |
| Grade 3 and 4 | 9 | 16 | 1,566 | 1.4 (0.9–2.3) | 0 |