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. 2018 Sep 20;13(9):e0203657. doi: 10.1371/journal.pone.0203657

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© 2018 Shimizu et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (A) We assessed RP relative gene expressions of inflammatory cytokines by normalizing the titers to 2^-ΔΔCt of normal individuals. The gene expression levels of normal individuals were defined as 1.000. IL1β gene expressions of RP patients were significantly higher than those of normal individuals in the presence of mitogen stimulation, 24 hours after the initiation of the cell culture. (B) We compared the gene expression data of the freshly isolated PBMC with those of cultured PBMC in patients with RP. After the initiation of the cell culture, in the absence of mitogen stimulation, TNFα gene expressions increased significantly in RP patients. With the stimulation, IL1β, IL6, and TNFα gene expressions increased significantly in RP patients. Relative gene expressions of RP patients against those of normal individuals were displayed with dot plots. A box-plot and a mean level (green line) of each group of RP patients and normal individuals were indicated.