Table 2. Comparisons between patients receiving and not receiving adequate empirical treatment for bacteremia with P. aeruginosa.
Patients receiving adequate empirical treatment (n = 151) | Patients receiving inadequate empirical treatment (n = 36) | ||||||||
---|---|---|---|---|---|---|---|---|---|
N | median | % | IQR | N | median | % | IQR | p-value | |
Demographics | |||||||||
Age (years) | 66 | 50–75 | 67 | 58–79 | 0.160 | ||||
Male gender | 99 | 65.6% | 29 | 80.6% | 0.082 | ||||
Underlying conditions | |||||||||
Charlson comorbidity index | 3 | 2–4 | 3 | 2–5 | 0.159 | ||||
Intravenous drug use | 15 | 9.9% | 2 | 5.6% | 0.412 | ||||
Immunosuppression | 68 | 45.0% | 21 | 58.3% | 0.151 | ||||
Solid organ transplant | 2 | 1.3% | 1 | 2.8% | 0.476 | ||||
Allogenic stem cell transplant | 11 | 7.3% | 2 | 5.6% | 1.000 | ||||
Autologous stem cell transplant | 4 | 2.6% | 1 | 2.8% | 1.000 | ||||
Neutropenia at diagnosis | 31 | 20.5% | 0 | 0.0% | 0.001 | ||||
Clinical presentation | |||||||||
PITT bacteremia score | 1 | 0–2 | 1 | 0–2 | 0.997 | ||||
Septic shock | 16 | 10.6% | 4 | 11.1% | 1.000 | ||||
ICU admission | 53 | 35.1% | 18 | 50.0% | 0.098 | ||||
Mechanical ventilation | 9 | 6.0% | 4 | 11.11% | 0.280 | ||||
Microbiological features | |||||||||
Number of positive bloodcultures | 2 | 1–4 | 2 | 2–3 | 0.721 | ||||
Polymicrobial sepsis | 55 | 36.4% | 15 | 41.7% | 0.559 | ||||
MDR P. aeruginosa | 7 | 4.6% | 5 | 13.9% | 0.057 | ||||
XDR P. aeruginosa | 1 | 0.66% | 0 | 0.0% | |||||
Origin of bacteremia | 0.215 | ||||||||
Urinary tract | 33 | 21.9% | 9 | 25.0% | |||||
Unknown | 27 | 17.9% | 12 | 33.3% | |||||
Vascular catheter | 31 | 20.5% | 3 | 8.3% | |||||
Respiratory tract | 22 | 14.6% | 9 | 25.0% | |||||
Abdominal | 14 | 9.3% | 2 | 5.6% | |||||
Skin/soft tissue | 11 | 7.3% | 1 | 2.8% | |||||
Surgical site infection | 6 | 4.0% | 0 | 0.0% | |||||
Bone/joint | 4 | 2.7% | 0 | 0.0% | |||||
Pancreaticobiliary | 3 | 2.0% | 0 | 0.0% | |||||
Outcome | |||||||||
Death during hospital stay | 22 | 14.6% | 11 | 30.6% | 0.024 | ||||
Death attributable to bacteremia | 18 | 11.9% | 10 | 27.8% | 0.017 |
Significant p-values are printed in bold; ICU: intensive care unit, MDR: multidrug-resistant, XDR: Extensively drug-resistance