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. 2018 Sep 20;13(9):e0203295. doi: 10.1371/journal.pone.0203295

Table 2. Comparisons between patients receiving and not receiving adequate empirical treatment for bacteremia with P. aeruginosa.

Patients receiving adequate empirical treatment (n = 151) Patients receiving inadequate empirical treatment (n = 36)
N median % IQR N median % IQR p-value
Demographics
Age (years) 66 50–75 67 58–79 0.160
Male gender 99 65.6% 29 80.6% 0.082
Underlying conditions
Charlson comorbidity index 3 2–4 3 2–5 0.159
Intravenous drug use 15 9.9% 2 5.6% 0.412
Immunosuppression 68 45.0% 21 58.3% 0.151
Solid organ transplant 2 1.3% 1 2.8% 0.476
Allogenic stem cell transplant 11 7.3% 2 5.6% 1.000
Autologous stem cell transplant 4 2.6% 1 2.8% 1.000
Neutropenia at diagnosis 31 20.5% 0 0.0% 0.001
Clinical presentation
PITT bacteremia score 1 0–2 1 0–2 0.997
Septic shock 16 10.6% 4 11.1% 1.000
ICU admission 53 35.1% 18 50.0% 0.098
Mechanical ventilation 9 6.0% 4 11.11% 0.280
Microbiological features
Number of positive bloodcultures 2 1–4 2 2–3 0.721
Polymicrobial sepsis 55 36.4% 15 41.7% 0.559
MDR P. aeruginosa 7 4.6% 5 13.9% 0.057
XDR P. aeruginosa 1 0.66% 0 0.0%
Origin of bacteremia 0.215
Urinary tract 33 21.9% 9 25.0%
Unknown 27 17.9% 12 33.3%
Vascular catheter 31 20.5% 3 8.3%
Respiratory tract 22 14.6% 9 25.0%
Abdominal 14 9.3% 2 5.6%
Skin/soft tissue 11 7.3% 1 2.8%
Surgical site infection 6 4.0% 0 0.0%
Bone/joint 4 2.7% 0 0.0%
Pancreaticobiliary 3 2.0% 0 0.0%
Outcome
Death during hospital stay 22 14.6% 11 30.6% 0.024
Death attributable to bacteremia 18 11.9% 10 27.8% 0.017

Significant p-values are printed in bold; ICU: intensive care unit, MDR: multidrug-resistant, XDR: Extensively drug-resistance