Table 4. Uni- and multivariable survival analyses (all-cause mortality) for patients with P. aeruginosa bacteremia.
| Univariable hazards ratio for all-cause mortality | Multivariable hazards ratio for all-cause mortality* | |||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p-value | HR | 95%CI | p-value | |
| Demographics | ||||||
| Age (years) | 1.03 | 1.00–1.05 | 0.029 | 1.02 | 0.99–1.05 | 0.120 |
| Male gender | 1.03 | 0.51–2.12 | 0.925 | |||
| Underlying conditions | ||||||
| Charlson comorbidity index | 1.08 | 0.93–1.26 | 0.321 | |||
| Intravenous drug use | 0.30 | 0.04–2.24 | 0.243 | |||
| Immunosuppression | 1.62 | 0.80–3.31 | 0.183 | |||
| Allogenic stem cell transplant | 0.37 | 0.08–1.61 | 0.185 | |||
| Neutropenia at diagnosis | 2.38 | 1.15–4.96 | 0.020 | 5.00 | 2.12–11.65 | <0.001 |
| Clinical presentation | ||||||
| PITT bacteremia score | 1.24 | 1.06–1.45 | 0.008 | 1.14 | 0.97–1.34 | 0.107 |
| Microbiological features | ||||||
| Polymicrobial sepsis | 1.01 | 0.84–1.21 | 0.916 | |||
| MDR/XDR P. aeruginosa | 1.49 | 0.56–3.94 | 0.423 | |||
| Origin of bacteremia | ||||||
| Known vs. unknown | 1.02 | 0.44–2.35 | 0.970 | |||
| Treatment | ||||||
| Inadequate empirical treatment | 2.51 | 1.21–5.21 | 0.014 | 3.32 | 1.40–7.89 | 0.006 |
| Definite combination treatment | 0.26 | 0.11–0.60 | 0.002 | 0.30 | 0.13–0.71 | 0.006 |
HR: hazard ratio, CI: confidence interval, MDR: multidrug-resistant, XDR: Extensively drug-resistance. Significant p-values are printed in bold
*The multivariable model includes age, neutropenia at diagnosis, PITT bacteremia score, inadequate empirical treatment and definite combination treatment